Emergency Medicine Journal

Background Emergency departments (EDs) in high-income countries face rising demand, workforce shortages and crowding. We investigated whether prehospital point-of-care blood gas analysis (BGA), used by emergency physicians, is associated with higher ambulatory treatment rates and improved patient selection for hospital admission. Methods We retrospectively analysed routinely collected data from a pilot implementation of a mobile blood gas analyser in physician-staffed emergency medical services (EMS) in Jena, Germany (July 2023 to May 2024). Adult emergency patients receiving prehospital BGA were compared with propensity score-matched EMS controls without BGA. Primary outcomes were the proportion treated on scene and, among transported patients, the hospital admission rate. Secondary outcomes were 30-day safety among ambulatory patients and associations between BGA parameters and disposition. We used standardised mean differences to assess balance and receiver operating characteristic analysis for lactate thresholds. Results Of 109 patients receiving prehospital BGA, 98 met inclusion criteria after excluding 9 patients with missing NACA scores, 1 on-scene death and 1 invalid age record; these were matched to 390 controls (total n = 488). Baseline demographics, severity and vital signs were well balanced. Ambulatory treatment was markedly higher in the BGA cohort compared with matched controls (27.6% vs 8.7%; OR 3.98, 95% CI 2.26 to 7.01; p<0.001). No ambulatory BGA patient required ED re-attendance or repeat EMS contact within 30 days. Among transported patients, 58% in the BGA cohort were admitted to hospital, compared with an overall regional ED conversion rate of approximately 30%. Lactate [&ge;]2.6 mmol/L was the most influential parameter for disposition decisions, with elevated lactate and acid-base disturbances strongly associated with transport and admission. Conclusion Prehospital BGA was associated with fourfold higher ambulatory treatment rates (27.6%) and a twofold higher ED conversion rate among the patients who were transported (58%), indicating improved risk stratification and resource allocation. These findings suggest that integrating objective biochemical data into prehospital assessment may enhance treat-and-refer decision-making and support more efficient use of limited emergency care capacity.

Objectives: Emergency department (ED) overcrowding is a persistent issue in European healthcare systems. A previous randomized controlled trial (RCT) concerning out of hours care in Antwerp (2019) demonstrated that a nurse-led triage tool, extending the Manchester Triage System (eMTS), could safely redirect low-acuity ED patients to a co-located General Practitioner Cooperative (GPC). This study reports a six-year follow-up assessing long-term efficiency, safety, and sustainability of this intervention. Methods: We performed a retrospective observational analysis of routine clinical data. Patients triaged at the ED and referred to the GPC were identified through electronic health records. Efficiency outcomes included the proportion of ED patients managed at the GPC, the proportion of GPC patients originating from the ED and their clinical characteristics. To assess safety, we analysed rates and characteristics of patients referred back from the GPC to the ED. A detailed case review was conducted for all back-referred patients. Results: Of the 110,941 triaged patients, 6,722 (6.1%) were managed at the GPC, accounting for 11% of all GPC consultations. Diverted patients typically presented with digestive, respiratory, and musculoskeletal complaints and had a clinical urgency which was mostly comparable to the overall GPC population. Only 3% of the patients diverted to the GPC were referred back to the ED, versus 5% of other GPC patients. Most back-referrals (83%) were managed on an outpatient basis; four major and 18 minor triage issues were identified, without evidence of increased morbidity. Conclusions: Six years post-trial, the nurse-led eMTS triage tool remains integrated into routine practice, with increasing efficiency and remaining safety without dedicated research resources nor a post implementation plan. Sustained adoption highlights its clinical feasibility and long-term safety. Future trials on triage and primary care should embed explicit post-trial implementation strategies to promote continuity and scalability of successful healthcare interventions. ClinicalTrials.gov Identifier: NCT03793972

Background: Potassium is involved in multiple physiological processes in the body, and hyperkalemia is a common, potentially life-threatening condition. Objective: The aim of our study was to examine the association between plasma potassium levels, and 30-day mortality in patients presenting to an emergency department with normo- or hyperkalemia. Design: Retrospective Cohort study. Setting: Emergency Departments in the Capital region of Denmark Participants: Persons attending Emergency Departments in the Capital Region of Denmark from 2017--2021 with a plasma potassium level of at least 3.5 mM measured within 4 hours after arrival. Measurements: The study was based on data from Danish National Registries and electronic patient records. We performed Kaplan-Meier survival analyses and unadjusted and adjusted cox regression analyses utilizing plasma [K+] 3.5--4.4 mM as the reference group for 30-day mortality hazard ratios (HRs). Results: A total of 248,453 patients were included with a median age of 60 years (Q1;Q3 42;75), and 6,959 (2.8%) died within 30 days. Mortality was 2.2% for potassium level 3.5--4.4 mM, 6.9% for 4.5--4.9 mM, 17.1% for 5.0--5.9 mM, and 26.9% for [&ge;] 6.0 mM. Unadjusted 30-day HRs were 3.2 (95%CI: 3.0--3.4) for [K+] 4.5--4.9 mM, 8.6 (95%CI: 7.9--9.3) for [K+] 5.0--5.9 mM, and 14.7 (95%CI: 12.5--17.0) for [K+] [&ge;]6.0 mM. Adjusted HRs were 1.4 (1.3--1.5), 2.10 (1.9--2.3), and 2.4 (2.0--2.8), respectively. Limitations: Risk of residual confounding. Missing data. No access to data regarding in-hospital treatment. Conclusion: Plasma potassium levels above 4.4 mM were associated with increased 30-day mortality among patients presenting to emergency departments. Primary funding source: Department of Emergency Medicine, Copenhagen University hospital, Bispebjerg and Frederiksberg Hospital.

ObjectiveTo explore emergency medical dispatchers (EMD) experiences of prioritising patients and stewarding ambulance resources when system capacity is constrained. DesignQualitative interview study using inductive qualitative content analysis. SettingEmergency medical communication centres (EMCCs) in Sweden operated by the national emergency call provider, responsible for receiving 112 calls and dispatching ambulances. ParticipantsThirteen purposively sampled EMDs with at least one year of professional experience. Data analysisInterviews were analysed inductively using qualitative content analysis (Elo and Kyngas) through open coding, grouping into subcategories and abstraction into generic categories and one main category. ResultsDispatchers described prioritisation under scarcity as system work that simultaneously addresses individual patient acuity and population-level readiness. One main category captured this work: Stewarding scarce response capacity. Three interrelated generic categories characterised stewardship: (1) prioritising by clinical urgency within geographic and operational constraints; (2) producing availability through anticipation, reassessment and queue governance in a virtual waiting room; and (3) coordinating response through information infrastructures and interprofessional collaboration. Across categories, dispatchers described redistributing risk across patients and time while attempting to avoid both under-response to urgent need and over-allocation that would leave areas without coverage. ConclusionsDispatch under scarcity is best understood as active stewardship of a safety-critical dispatch queue. Strengthening patient safety therefore requires organisational support for reassessment and escalation during prolonged waits, and governance that makes queue dynamics and geographic coverage trade-offs visible, rather than relying solely on initial triage decisions or aggregate response-time targets. Strengths and limitations of this studyO_LIStrengths and limitations of this study C_LIO_LIAn inductive qualitative content analysis allowed categories to emerge from dispatchers own descriptions, rather than imposing predefined theoretical frameworks. C_LIO_LIInclusion of emergency medical dispatchers with varied ages, professional experience and EMCC locations enhanced the richness of the data and potential transferability. C_LIO_LIAnalyst triangulation, an explicit abstraction pathway and data-to-category quotations strengthened analytic transparency and trustworthiness. C_LIO_LIInterviews were conducted via video, which may have limited access to non-verbal cues compared with in-person interviews. C_LIO_LIThe study was conducted within a single national dispatch system, and participation was voluntary, which may limit transferability and introduce self-selection of more experienced or engaged dispatchers. C_LI

BackgroundIn the United States, emergency clinicians are often the first to care for injured patients in the hospital setting. To better understand end-user needs, we evaluated emergency clinician priorities and preferences in accessing, interpreting, and applying trauma clinical guidance. MethodsEmergency clinicians were recruited via email for semi-structured video conference interviews. Rapid directed qualitative analysis of interview notes and audio recordings yielded initial insights about guidance barriers and facilitators. A subsequent quantitative survey was developed and distributed via email to members of relevant professional associations. Survey results were analyzed using descriptive and inferential statistics. ResultsTwelve emergency clinicians participated in interviews. 154 eligible participants responded to the survey. Clinicians expressed support for trauma clinical guidance overall but often find resources lacking. Barriers to guidance usage include lack of awareness, difficulty locating guidance, and cumbersome design. Clinical guidance should be objective, concise, updated, and easy-to-use at bedside. The strongest determinant of guidance usability was being quickly understood in a time-pressured situation. Clinicians prefer to access guidance through mobile applications or multi-modal channels. Rural clinicians reported additional difficulties in staffing and having resources needed to follow guidance. ConclusionWhen developing trauma clinical guidance, the trauma community should continue to consider the variety of end users and clinical settings, including emergency clinicians. Developing mobile device-friendly, quickly understandable guidance should be a priority for authors of trauma clinical guidance.

ObjectiveWe aimed to prospectively validate and compare published prediction models and clinician-assigned triage categories for early trauma care. DesignProspective multicentre cohort study. SettingThree public hospitals in urban India: one secondary care hospital in Mumbai and one tertiary care teaching hospitals in Delhi and Kolkata each. ParticipantsAdult patients aged over 18 years presenting to the emergency department with a history of trauma between 2016 and 2022. A total of 13,041 patients were included in the final analysis. MethodsWe externally validated five published trauma prediction models (GAP, Gerdin, KTS, MGAP, and RTS) and clinician-assigned triage categories based on initial assessment. The primary outcome was 30-day all-cause mortality. Models were recalibrated using a separate updating sample prior to evaluation, and model performance was assessed in terms of discrimination (AUC), calibration (calibration slope and plots), and decision curve analysis. ResultsAll models and clinician gestalt-based triage demonstrated excellent discrimination (AUC range: 0.90-0.96) and good calibration after updating. The GAP model achieved the highest AUC (0.96, 95% 0.94-0.97), and RTS demonstrated the highest sensitivity (0.70). ConclusionSimple, physiology-based prediction models and clinician gestalt both demonstrated excellent performance in predicting 30-day mortality among adult trauma patients in Indian emergency departments. These findings provide a practical foundation for further development of trauma triage systems.

BackgroundAdvanced Practice Providers (APPs), including physician assistants and nurse practitioners, represent a growing proportion of the emergency medicine workforce, including in high-acuity community emergency departments (EDs). Despite this growth, many sites lack formal onboarding structures, particularly for new graduate or inexperienced APPs transitioning to practice. Unlike postgraduate residencies and fellowships, limited literature exists on structured onboarding models outside academic settings. This study evaluated the feasibility and perceived impact of a structured onboarding program for APPs in a non-academic community ED. MethodsThis mixed-methods feasibility study was conducted at a single-site community ED without an existing formal onboarding process. New graduate or inexperienced APPs hired within 12 months of program implementation completed a post-intervention survey assessing satisfaction across five domains derived from a conceptual framework of human resource practices and retention. Quantitative data was collected using 5-point Likert-scale items, and qualitative data was obtained through open responses. Leadership and preceptors completed a secondary survey evaluating feasibility and perceived impact. Descriptive statistics and thematic analysis were performed. ResultsFour new graduate APPs (100% response rate) completed the post-implementation survey. Mean scores across domains ranged from 3.33 to 5.00, with highest ratings observed in supervisor support (mean = 5.00), employee engagement (4.33), and alternative training via online modules (4.67). Qualitative themes included clear communication of expectations, value of asynchronous educational modules, and strong mentorship support. Fifteen leaders and preceptors reported that although the program required additional effort, it improved tracking of APP progress, preparedness for transition to practice (4.67), and was perceived as worthwhile to reduce attrition. ConclusionsA structured onboarding program for new graduate APPs in a community ED was feasible, well accepted, and perceived to support transition to practice. These findings support the need for further study of structured onboarding as a scalable strategy to enhance preparedness, engagement, and potential retention in high-acuity clinical settings.

ObjectivesEmergency Medical Services (EMS) demand is increasing, with a growing proportion of low-acuity encounters. Prior studies are limited by regional sampling, inconsistent definitions, narrow observation periods, and limited theoretical grounding. The objective of this study was to identify predisposing, enabling, and need-based factors associated with EMS transport among low-acuity emergency department (ED) patients, guided by Andersens Behavioral Model of Health Services Use. MethodsWe conducted a secondary, retrospective observational study using a 10% random sample of multicenter electronic health record (EHR) data from 21 emergency departments in the southeastern United States. To be eligible to be included in the analysis, the visit had to be for: (1) patient age >17 years of age, (2) occur between January 1, 2016, to April 29, 2025, (3) triaged as Emergency Severity Index (ESI) 4 or 5, and (4) ended in a final visit disposition of being discharged. The primary outcome was EMS utilization. Independent variables were categorized as predisposing, enabling, or need-based factors according to Andersens model. We used multivariable logistic regression to estimate adjusted odds ratios (aORs) with 95% confidence intervals. ResultsAmong 41,772 low-acuity ED encounters, 3,233 (7.7%) arrived by EMS. Increased odds of EMS use were associated with older age (per 10-year increase; aOR 1.30, 95% CI=1.27-1.33), male sex (aOR 1.20, 95% CI=1.12-1.30), being retired or disabled (aOR 3.60, 95% CI=3.15-4.10), being unemployed (aOR 2.26, 95% CI=2.04-2.52), having a nighttime presentation (aOR 1.63, 95% CI=1.51-1.76), and mental health diagnosis (aOR 1.76, 95% CI=1.62-1.90). Protective factors included White race (aOR=0.89, 95% CI=0.83-0.96), established primary care (aOR=0.57, 95% CI=0.57-0.62), weekend presentation (aOR 0.91; CI = 0.84-0.99), and visits during (aOR 0.63, 95% CI=0.55-0.71) or after (aOR 0.54, 95% CI=0.48-0.61) the COVID-19 period. Rurality, insurance, and primary language were not associated with EMS use. ConclusionsPredisposing and enabling factors were the predominant drivers of low-acuity EMS utilization in this sample. Expanding access to primary care and behavioral health services, especially for older patients, may reduce EMS use for low-acuity complaints while preserving EMS capacity for higher-acuity emergencies.

ObjectiveTo compare the efficacy and safety of etomidate versus ketamine as induction agents for rapid sequence intubation in critically ill adults, focusing on 28-day mortality and post-intubation hypotension. Data SourcesPubMed, Embase, and the Cochrane Library were systematically searched from inception to January 2026. Reference lists of included studies were also manually screened. Study SelectionWe included randomized controlled trials (RCTs) comparing single-dose intravenous ketamine versus etomidate for emergency rapid sequence intubation in critically ill adults ([&ge;] 18 years) in non-operating room settings (e.g., intensive care unit or emergency department). Data ExtractionTwo investigators independently screened records, extracted data using a standardized form and assessed the risk of bias using the RoB 2 tool. The certainty of evidence was evaluated using the GRADE framework. Data SynthesisSix RCTs comprising 4,108 patients (2,046 assigned to ketamine and 2,062 to etomidate) were included. The pooled analysis showed no statistically significant difference in 28-day mortality between the ketamine and etomidate groups (39.0% vs. 40.3%; relative risk [RR] 0.96; 95% CI, 0.89-1.03; p=0.29; I{superscript 2}=11%). In a prespecified subgroup analysis of patients with sepsis (n=1,546), mortality also did not differ significantly (RR 0.94; 95% CI, 0.86-1.03). However, ketamine was associated with a statistically significant increase in the incidence of post-intubation hypotension (14.2% vs. 11.3%; RR 1.25; 95% CI, 1.01-1.53; p=0.04; I{superscript 2}=0%). No significant differences were observed regarding peri-intubation cardiac arrest, first-attempt intubation success, or ventilator- and intensive care unit-free days. ConclusionsThere is no statistical difference in 28-day mortality between etomidate and ketamine for emergency intubation in critically ill adults, including those with sepsis. The higher incidence of post-intubation hypotension with ketamine suggests etomidate presents a more favorable hemodynamic safety profile in this setting. Key pointsO_ST_ABSQuestionC_ST_ABSDoes the choice between etomidate and ketamine for emergency intubation in critically ill patients impact 28-day mortality? FindingsIn this systematic review and meta-analysis of randomized controlled trials, there was no statistically significant difference in 28-day mortality between patients induced with ketamine (39.0%) and those induced with etomidate (40.3%). MeaningThe use of etomidate versus ketamine for rapid sequence intubation does not alter 28-day mortality, indicating that the choice of induction agent should be individualized.

BackgroundStandardized training and competency testing is needed for appropriate point-of-care ultrasound (POCUS) clinical use. Our study objective assesses a low-fidelity simulation pig model workshop and tests the knowledge and technical skills of emergency medicine (EM) clinicians when performing simulated ultrasound-guided serratus anterior nerve block (UG-SANB). MethodsEM residents, attendings, and advanced practice providers (APP) participated in a prospective cohort study, completing a one-time simulation-based UG-NB training session at a single academic medical center between November 2024 to February 2025. Training model acceptability, appropriateness, and feasibility was assessed using the validated AIM-IAM-FIM tool (pre/post-surveys). Effectiveness outcomes were participant knowledge score, technical skill score, and self-rated confidence in performing NBs pre-, post-, and 3-months post-intervention. Clinical ED-performed ultrasound-guided nerve blocks were reported pre-/post-intervention. Scores were summarized using mean (S.D.) and total question percent correct. Paired individual assessments were compared pre/post-intervention using paired t-tests and group assessments using t-tests for normal data distribution. Results63/104 ED providers (60.6%) responded to surveys pre-intervention and 57 post-intervention (54.8%). 63 providers (16 EM attendings, 33 residents, and 14 APPs) underwent SANB training and testing. Participant survey responses reported the training model was acceptable, appropriate, and feasible (at least 54/57 agreed or strongly agreed for all three). Mean knowledge scores were 85% (SD 14.8%) post- and 70% (SD 18.2%) 3-months post-workshop. Mean technical skills exam scores were 98% (SD 4.5%) post- and 95% (5.8%) 3-months post-intervention. Perceived confidence in teaching clinical NBs increased pre-/post-intervention (from 11.3% to 58.2%) and for SANB (3.2% to 70.2%). Clinically performed NBs at pre and post were 21 and 15 respectively. ConclusionEmergency clinicians knowledge, technical skills, and confidence scores increased after an UG-NB training intervention. This standardized, reproducible simulation model could improve clinical skills and patient care outcomes but needs additional steps to increase clinical UG-NB performance.

RationaleCardiopulmonary resuscitation (CPR) aims to provide oxygen to vital organs through chest compressions and ventilations, until return of spontaneous circulation (ROSC) is achieved. A major barrier to effective oxygenation during CPR is atelectasis, which impairs gas exchange and results in hypoxemia--a condition strongly associated with decreased rates of ROSC and worsened neurological outcomes. Positive end-expiratory pressure (PEEP) is routinely used in critical care to prevent atelectasis and improve oxygenation. During CPR, however, its use is inconsistent and subject of debate. This reflects long-standing theoretical concerns that PEEP may reduce venous return, lower cardiac output, and impair the chances of successful defibrillation. However, emerging experimental and observational data suggest that PEEP may actually improve oxygenation, cardiac output, oxygen delivery, and rates of ROSC during CPR. We hypothesize that applying PEEP during CPR improves neurologically favorable survival. Given its simplicity, negligible cost, and widespread availability, PEEP has the potential to enhance outcomes from cardiac arrest in a scalable and resource-efficient manner. ObjectiveTo determine whether, during CPR with manual ventilation and after placement of a supraglottic airway device (SAD) or endotracheal tube (ETT), using a valve that generates 8 cm H2O PEEP compared with a sham valve providing zero end-expiratory pressure (ZEEP) improves neurological outcomes at discharge. Study designThe REVIVE-PEEP study is an investigator-initiated, pragmatic, registry-based, multicenter, parallel-group, triple-blind randomized controlled superiority clinical trial in the ARREST registry. Study populationThe principal stratum comprises adult patients with out-of-hospital cardiac arrest (OHCA) in whom advanced airway management is performed, defined by placement of a SAD or ETT, who subsequently undergo manual positive-pressure ventilation during CPR. The target sample size within this principal stratum is 2,400 patients. InterventionParticipating ambulance services will use pre-assembled CPR kits, containing a bag-valve-mask system with either a PEEP valve or a sham valve. These kits will be 1:1 pre-randomized, with the PEEP valve delivering 8 cm H2O of PEEP and the sham valve delivering 0 cm H2O of PEEP (i.e. ZEEP), alongside the standard advanced life support protocol. Main study parameters/endpointsThe primary estimand is the treatment effect on neurological outcome at hospital discharge, assessed by the utility-weighted modified Rankin Scale within the principal stratum. Key secondary outcomes include ROSC, 30-day survival and quality of life at 6 months. Nature and extent of the burden and risks associated with participation, benefit and group relatednessThis studys intervention involves only a minor adjustment to ventilation management during cardiac arrest and requires no additional procedures. The study design imposes no additional clinical tasks on ambulance professionals during resuscitation, allowing them to maintain full focus on patient care; the only study-related action is recording the study device number in the case report form after the resuscitation attempt. The risks associated with participation are minimal. There may be a negligible increase in thoracic impedance that theoretically could influence defibrillation; however, modern defibrillators automatically adjust delivered energy based on pre-defibrillation thoracic impedance. Leakage around the SAD is a known issue that could reduce ventilation efficiency and may be exacerbated by the intervention, but existing guidelines allow for switching to a 30:2 compression:ventilation ratio in such cases. Lastly, although higher levels of PEEP have been associated with reduced cardiac output during CPR, the PEEP level used in this study remains under the maximum tolerated dose. Potential benefits include improved oxygenation and ventilation, reduced afterload, and improved cardiopulmonary interactions, which may increase the likelihood of successful resuscitation and favorable neurological outcomes. Improved oxygenation may also increase the likelihood of successful defibrillation.

BackgroundRural emergency departments (EDs) are critical to ensuring equitable access to acute care, yet face persistent systemic challenges. In Quebec, Canada, reforms to healthcare governance, funding and resource allocation, and service delivery have transformed rural ED operations. This study aimed to document characteristics, challenges, and improvement priorities for all rural EDs in the province. MethodsA participatory mixed-methods design was used. 26 rural EDs in Quebec were included. Data sources comprised administrative statistics, structured site surveys, individual stakeholder semi structured interviews, and a validation survey of identified local champions. Analyses comprised a triangulation of the quantitative and qualitative data using transversal thematic analysis to determine common issues. Potential solutions identified were validated through stakeholder questionnaires. The study was reported in accordance with the COREQ reporting guideline. ResultsMost respondents were women (64%) and professionals with more than 5 years of experience. Four main themes were identified: governance, healthcare organization, access to resources, and professional practice. Governance challenges included reduced local autonomy, administrative complexity, and budgeting models poorly adapted to rural realities. Participants emphasized the need for standardized but locally flexible administrative processes, regional emergency service managers, and rural-sensitive performance metrics. Organizational barriers included geographic isolation, limited access to primary care, and difficulties with interfacility transfers due to referral-center capacity and ambulance shortages. Resource constraints centered on shortages of human resources, diagnostic services and specialty coverage, especially anesthesia, obstetrics, and psychiatry. Professional practice was shaped by the need to maintain broad competencies in low-volume contexts, while contending with professional isolation and proximity to patients. Local champions prioritized expanding telemedicine, strengthening prehospital services, enhancing continuing education, and implementing tailored recruitment strategies. ConclusionThis study provides the first province-wide documentation of characteristics, challenges, and improvement priorities for all rural EDs. Findings highlight the need for systemic reforms that restore local decision-making authority, strengthen transfer and prehospital capacity, expand telehealth and specialty access, and support professional development. These results provide a foundation for evidence-based policies and actions to sustain equitable emergency care in rural regions.

BackgroundSalbutamol is the most commonly prescribed inhaler for adults discharged from the Emergency Department (ED) with uncontrolled asthma. However newer options, e.g. Maintenance and Reliever Therapy (MART), are now recommended due to growing concerns over risks linked to salbutamol over-prescription. Transitioning to new inhalers requires support for both patients and healthcare professionals (HCP). This paper outlines how we developed an implementation package based on evidence, theory and the person-based approach to support asthma medication optimisation in the ED. MethodsThe purpose of this study was to use person-based intervention development methods in a three phase process: (1) understanding behaviour - collating and synthesising evidence from in-depth interviews with the target population (patients and HCPs); secondary deductive analysis using the theoretical domains framework (TDF) to understand barriers and facilitators to prescribing; developing guiding principles and logic model based on underlying theory (2) identifying behavioural content and implementation options - behaviour change techniques were selected and translated into intervention content (3) intervention materials developed and refined with input of stakeholders. ResultsWe identified modifiable target behaviours for HCPs to support guideline-based care in the ED. These included identifying eligible patients, communicating rationale, providing patients with inhaler and resources, and communicating changes to primary care. Key theoretical domains included knowledge, skills, addressing beliefs about consequences, and targeting professional role perceptions. These domains were targeted through a clinical decision aid and training materials for ED HCP, template discharge summary for primary care, and visual and written materials for patients. Minor refinements were made based on stakeholder feedback (six ED doctor think-aloud interviews; two patient workshops with eight and five participants respectively; and 12 survey responses to final draft of video). ConclusionWe developed an intervention grounded in theory, evidence, and stakeholder feedback aimed at promoting and supporting delivery of guideline recommendation. KEY MESSAGESO_ST_ABSWhat is already knownC_ST_ABSED visits represent teachable moments where patients may be receptive to optimising asthma medication, yet guideline-concordant prescribing is often limited in fast-paced settings. What this study addsThis study describes AMEND, a behaviourally informed implementation package including a clinical decision aid, HCP training, and patient-facing materials, designed to support initiation of Maintenance and Reliever Therapy (MART) at discharge. Using stakeholder-informed, iterative development, the package was feasible to integrate into routine ED workflows. How this study might affect research, practice or policyFindings highlight how theory-driven interventions can translate guidelines into practice, improve adherence, and potentially reduce repeat ED attendances.

BackgroundThe COVID-19 pandemic exposed critical shortages of mechanical ventilators, particularly in low-resource settings. Disruptions in global supply chains and dependence on specialized components highlighted the need for scalable, locally manufacturing alternatives for emergency respiratory support. AimTo describe and evaluate a simplified, supply-chain-independent mechanical ventilator assembled from widely available automotive and simple hardware components, and intended as a last-resort solution. MethodsThe ventilator is based on a reciprocating air pump driven by an automotive windshield wiper motor coupled to parallel shaft bellows and readily assembled passive membrane valves, only requiring materials available from standard hardware retailers, minimal tools, and basic manual skills. Ventilator performance was assessed through bench testing using a patient model simulating severe lung disease in an adult (R=20 cmH2O{middle dot}s/L, C=15 mL/cmH2O) and pediatric (R=50 cmH2O{middle dot}s/L, C=10 mL/cmH2O) patients. Realistic proof of concept was performed in four mechanically ventilated 50-kg pigs. ResultsThe device delivered tidal volumes up to 600 mL and respiratory rates up to 45 breaths/min with PEEP up to 10 cmH2O, covering pediatric and adult ventilation ranges. In vivo testing showed that the ventilator maintained arterial blood gases within the targeted range. Technical details for ventilator construction are provided in an open-source video tutorial. DiscussionThis low-cost ventilator demonstrated adequate performance under demanding conditions. Although not a substitute for commercial intensive care ventilators, its simplicity, autonomy, and independence from fragile supply chains provide a potentially life-saving option in resource-constrained emergency scenarios.

IntroductionRecent evidence has shown that vitamin C has analgesic properties in immediate postoperative context. However, while a clinical trial is currently underway to evaluate vitamin C for reducing opioid consumption in acute musculoskeletal (MSK) injuries emergency department (ED) patients, its direct analgesic effect in this population has not yet been established. This pilot study evaluated the feasibility of conducting a randomized placebo-controlled trial to determine the analgesic effect of vitamin C alone compared with placebo in acute MSK injured ED patients. MethodsWe conducted a double-blind, randomized controlled pilot trial stratified by fracture status in a tertiary care center. Adults ([&ge;]18 years) presenting to the ED with MSK injuries of [&le;] 48 hours duration and pain intensity >3/10 were randomized to receive vitamin C 900 mg twice daily for three days or placebo. Participants completed a six-day diary (electronic or paper) and were contacted on day six to document analgesic use, treatment adherence, and pain intensity. ResultsOverall, 147 patients were screened; 63 (42.9%) were excluded, 24 (16.4%) refused, leaving 60 (41.1%) participants, with a consent rate of 13.0/month. Mean age (SD) was 41.8 years (14.23) and 50% were female. Lost to follow-up rate differed between participants with electronic diary (n=7; 16.7%) and participants with paper diary (n=10; 55.6%). Patients compliance with treatment was 97.6%. The least-squares mean difference between group A and group B in the time-weighted sum of pain intensity differences over 72 hours (SPID72) was 348.7 (95% confidence interval [CI]:-698.9 to 1396.4) for the intention-to-treat analysis and 357.6 (95%CI:-709.67 to 1424.82) for the per-protocol analysis. ConclusionThis pilot study supports the feasibility of a larger randomized controlled trial on the analgesic properties of vitamin C for acute MSK injured ED patients. Strategies to reduce the missed patients and lost to follow-up rates are proposed. Trial registration numberNCT06306183, ClinicalTrials.gov

BackgroundPlatform trials are an efficient trial design which enable testing of multiple interventions simultaneously. They could advance knowledge of treatments for intracerebral haemorrhage (ICH). We aimed to investigate the views of clinicians involved in stroke research on recruitment to a future platform trial for ICH. MethodsBetween April and July 2025, we conducted a UK-wide online survey of clinicians actively involved in stroke research using convenience sampling through professional organisations. Participants considered factors related to the consent process and research environment and could provide optional free text responses about additional barriers or facilitators to recruitment. We used descriptive statistics for quantitative data and content analysis for qualitative data. ResultsAmong 73 respondents, 46 (63%) were female, 36 (50%) were stroke physicians, 24 (34%) nurses, 6 (8%) allied health professionals, and 7 (10%) were in other roles. 36 (49%) had >20 years clinical experience, 45 (61%) reported spending <10% of their role in research. 66 (91%) thought that a platform trial would be a good option for testing interventions for patients with stroke due to ICH. Across 11 modifiable factors, clinicians most frequently rated perceived importance of the research question as a facilitator of recruitment (94%), while clinician preference for specific treatments was most frequently rated as a barrier (48%). Two themes emerged from free text responses: study design and infrastructure. Regarding study design respondents perceived consent procedures (n=9), study materials (n=8), study procedures (n=8), eligibility assessment (n=6), the research question (n=3) and randomization (n=3) as important for a future platform trial. Regarding infrastructure, emergent factors were staffing (n=17), local research culture and capacity (n=9), research governance and delivery (n=6), and training (n=6). ConclusionThe overwhelming majority of respondents from the UK clinical stroke community supported a platform trial for ICH, although the influence of survey responder bias is unknown.

BackgroundSouth Africas public healthcare system serves most of the population through approximately 3,900 primary healthcare clinics characterised by long waiting times and high volumes of repeat-prescription visits. No published pre-arrival digital triage system operates across all 11 official South African languages while aligning with the South African Triage Scale (SATS). This paper reports the design and preliminary safety validation of BIZUSIZO, a hybrid deterministic-AI WhatsApp triage system. MethodsBIZUSIZO delivers SATS-aligned triage via WhatsApp, combining AI-assisted free-text classification (Claude Haiku 4.5) with a Deterministic Clinical Safety Layer (DCSL) that overrides AI output for 53 clinical discriminator categories (14 RED, 19 ORANGE, 20 YELLOW) coded in all 11 official languages and independent of AI availability. A five-domain risk factor assessment can only upgrade triage level. One hundred and twenty clinical vignettes in patient language (English, isiZulu, isiXhosa, Afrikaans; 30 per language) were scored against a developer-assigned gold standard with independent blinded nurse review. A 121-vignette multilingual DCSL safety consistency check across all 11 languages and a 220-call post-hoc framing sensitivity evaluation (110 paired vignettes) were also conducted. ResultsUnder-triage was 3.3% (4/120; 95% CI: 0.9%-8.3%) with no RED under-triage; exact concordance was 80.0% (96/120) and quadratic weighted kappa 0.891 (95% CI: 0.827-0.932). One two-level under-triage was observed on a non-RED presentation (V072, isiXhosa burns vignette, ORANGEGREEN); one two-level over-triage was observed (V054, isiZulu deep laceration, YELLOWRED). In the framing sensitivity evaluation, AI-only classification achieved 50.9% RED invariance under adversarial framing; full-pipeline classification achieved 95.0% in four validated languages, with the DCSL rescuing 18 of 23 AI drift cases. ConclusionsA hybrid deterministic-AI triage system with DCSL-based emergency detection achieved zero RED under-triage and consistent RED detection across all 11 official languages. The 16.7% over-triage rate falls within published South African SATS ranges (13.1-49%). A single two-level under-triage event was observed on an isiXhosa burns vignette (ORANGEGREEN) and is discussed in Limitations. Findings are preliminary; prospective validation against independent nurse triage is the necessary next step.

Background and aimsWe evaluated the efficacy of the Stroke Riskometer mobile phone App to change the Lifes Simple 7(R) (LS7(R)) risk factor score at 6 months post-randomisation. Methods and designThis Phase III, prospective, outcome assessor-blinded, 2-arm randomised controlled trial (RCT) in Australia and New Zealand recruited participants from August 2021 to January 2024. Inclusion criteria: age [&ge;]35 and [&le;]75 years; [&ge;]2 risk factors; smartphone ownership; no cardiovascular disease history. The intervention group was given access to the App; the usual care group received one e-mail with generic risk factor information. The primary outcome was the mean between group difference in LS7(R) (score 0 [poor] to 14 [ideal] comprising blood pressure, cholesterol, glucose, body mass index, smoking, physical activity and diet) from baseline to 6 months post-randomisation. Secondary outcomes were between group changes in individual LS7 items. Analyses were performed using intention to treat (ITT) principles with ANCOVA and linear mixed models to examine differences between groups, with pre-specified per protocol and subgroup analyses. ResultsWe randomised 862 participants (mean {+/-} SD age 58{+/-}11 years; 63% women; 74% Caucasian). At 6 months post-randomisation in ITT analyses, the mean difference between usual care (n=433) and intervention (n=429) groups in the change in LS7(R) score from baseline was 0.03 (95% CI -0.19, 0.25, p=0.79). Per protocol analyses (n=320 usual care; n=276 intervention) were similar (mean difference in change 0.11 95% CI -0.12, 0.34, p=0.34). Compared to usual care in ITT analyses, the intervention group had a borderline increase in metabolic equivalent of task (MET) minutes/week of physical activity (313.42 95% CI -2.80, 629.65, p=0.05), with no differences in other LS7(R) items. DiscussionAmong a general population aged 35 to 75 years with [&ge;]2 stroke risk factors, there was no evidence that having access to the App changed overall LS7(R) scores at 6-month follow-up. Participants in the intervention group did have a small increase in physical activity, compared to the usual care group after 6 months, but not other individual risk factors.

Sepsis is a complex condition with a time-dependent evolution. Longitudinal biomarker dynamics could help us to better characterise sepsis. We hypothesised that the kinetics of biomarkers are associated with sepsis and with the intensity of organ dysfunction, and may have predictive capacity for patient survival. This single-centre, prospective, observational study included adult patients presenting to the Emergency Department (ED) with suspected infection. Patients were included in the study if they had a National Early Warning Score 2 (NEWS 2) of 3 or higher. Blood samples were obtained at baseline, 4hs and 24 hs. Linear mixed models were constructed to analyse the association between biomarker concentrations over time, sepsis diagnosis and organ dysfunction severity. Joint models were used to evaluate the predictive ability of individual biomarker kinetics during the first 24 hours for in-hospital mortality Of 214 screened patients, 173 patients were analysed, and 137 (79%) developed sepsis. Linear mixed models revealed time-dependent decreases in IL10 ({beta} -0.016, 95%CI -0.028 to -0.004), IL1RN ({beta} -0.014, 95%CI -0.024 to -0.004), and IL6 ({beta} -0.012, 95%CI -0.024 to 0.00). Sepsis was associated with higher IL1RN ({beta} 0.378, 95%CI 0.153-0.603), and TNFRSF1A ({beta} 0.40, 95%CI 0.21-0.58); only models evaluating IL6 showed significant interaction between sepsis and time ({beta} -0.14, 95%CI -0.028 to 0.00). SOFA correlated with elevated IL10 ({beta} 0.048, 95%CI 0.021-0.075), IL1RN ({beta} 0.044, 95%CI 0.017-0.071), CCL2 ({beta} 0.046, 95%CI 0.021-0.071), TNFRSF1A ({beta} 0.050, 95%CI 0.030-0.070), and PCT ({beta} 2.63, 95%CI 1.32-3.93); the interaction between SOFA score and time was significant only for IL6 ({beta} -0.003, 95%CI -0.005 to -0.001). Joint survival models (adjusted for age and highest SOFA) identified IL8 (HR 0.655, 95% CrI 0.582-0.728), TNFRSF1A (HR 0.505, 95% CrI 0.419-0.682), and PCT (HR 1.004, 95% CrI 1.001-1.008) as predictors. ConclusionSepsis diagnosis and severity of organ dysfunction may be associated with higher levels and kinetic values of inflammatory biomarkers such as IL1RN and TNFRSF1A. IL6 levels showed a significant association for the interaction of time with both sepsis diagnosis and SOFA score. TNFRSF1A, IL8 and PCT dynamics were found to be associated with survival and could be useful in developing prognosis tools.

BACKGROUND Point-of-care (POC) high-sensitivity cardiac troponin (hs-cTn) testing has the potential to expedite decision-making and reduce emergency department (ED) length of stay for patients presenting with possible myocardial infarction (MI) by ensuring that results are consistently available when looked for by clinicians. We assessed the real-life effectiveness and safety of implementing POC hs-cTn testing in the ED. METHODS We conducted a pragmatic, stepped-wedge cluster randomized trial. The control arm was usual care with an accelerated diagnostic pathway utilizing a single-sample rule-out step with a central laboratory hs-cTn assay. The intervention arm used the same pathway with a POC hs-cTnI. The primary effectiveness outcome was ED length of stay assessed using a generalized linear mixed model, and the safety outcome was 30-day MI or cardiac death. RESULTS Six sites participated with 59,980 ED presentations (44,747 individuals, 61{+/-}19 years, 49.5% female) from February 2023 to January 2025, in which 31,392 presentations were during the intervention arm. After adjustment for co-variates associated with length of stay, the intervention reduced length of stay by 13% (95% confidence intervals [CI], 9 to 16%. P<0.001), corresponding to a reduction of 47 minutes (95%CI, 33 to 61 minutes) from a mean length of stay in the control arm of 376 minutes. The 30-day MI or cardiac death rate was similar in the control and intervention arms (0.39% and 0.39% respectively, P=0.54). CONCLUSIONS Implementation of whole-blood hs-cTnI testing at the POC into an accelerated diagnostic pathway was safe and reduced length of stay in the ED compared with laboratory testing.